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Year : 2022  |  Volume : 12  |  Issue : 4  |  Page : 183-187

Cold agglutinin autoimmune haemolytic anaemia as an initial presentation of diffuse large B cell lymphoma: A case study

1 Department of Blood Transfusion Medicine, Sir Ganga Ram Hospital, New Delhi, India
2 Department of Clinical Hematology, Sir Ganga Ram Hospital, New Delhi, India
3 Department of Research, Sir Ganga Ram Hospital, New Delhi, India

Correspondence Address:
Dr. Rashmi Rana
Department of Research, Sir Ganga Ram Hospital, New Delhi -110060
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/cmrp.cmrp_115_21

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Cold agglutinin disease, commonly affecting females in the their seventh decade of life, is otherwise a rare entity and has an incidence of one case per million people per year. Cold reactive antibody is associated with autoimmune haemolytic anaemia (AIHA) in approximately 20% of the cases. Although the occurrence of AIHA in patients with non-Hodgkin's lymphomas is well known, aggressive lymphomas such as diffuse large B cell lymphoma (DLBCL) initially presenting as cold agglutinin AIHA is extremely rare. Here, we describe a case of DLBCL presenting few months before the diagnosis as cold antibody-AIHA.xs

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