| ORIGINAL ARTICLE |
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| Year : 2022 | Volume
: 12
| Issue : 3 | Page : 114-117 |
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To study the role of magnesium and Gamma- glutamyl transferases in alcoholic liver disease
Kapila Gaikwad1, Sohan Selkar2, Sanjay Agrawal3
1 Department of Biochemistry, Shyam Shah Medical College, Rewa, Madhya Pradesh, India
2 Department of Musculoskeletal Sciences, Datta Meghe College of Physiotherapy, Nagpur, Maharashtra, India
3 Department of Preventive and Social Medicine, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India
Correspondence Address:
Dr. Kapila Gaikwad
New Doctor's Colony, F16/1, Ground Floor, Arjun Nagar, Near Dhobia Tank, Rewa - 486 001, Madhya Pradesh
India
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/cmrp.cmrp_63_21
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Aim: To study the role of magnesium and gamma- glutamyl transferases in alcoholic liver disease.
Objectives: (1) To estimate serum magnesium and serum glutamyl-transferases (GGT) in alcoholic liver disease. (2) To estimate liver enzymes Alanine Transaminases (ALT), Aspartate Transaminases (AST), Alkaline Phosphatase (ALP), and Total protein and Albumin in alcoholic liver disease. (3) To correlate serum magnesium with all liver enzymes. (4) To correlate serum GGT with all liver enzymes.
Materials and Methods: All liver enzymes, serum magnesium, serum GGT, total protein and albumin were estimated in 50 alcoholic liver disease patients and 50 normal subjects on Trivitron Dirui autoanalyzer.
Results: Significant difference was found between mean values of cases and controls in Mg, GGT, AST, ALT, Alkaline phosphatase, and Albumin (P<0.05). Positive correlation was found between Mg with GGT, ALT, Total proteins and Albumin. This indicates that the higher(lower) values of Mg are associated with higher(lower) values of GGT, ALT, Total proteins, and Albumin. But the result were not statistically significant.(P >0.05).
Conclusion: Chronic alcoholic liver disease significantly elevates Gamma-glutamyl transferase. Hypomagnesemia is also seen in alcoholic liver disease. Gamma-glutamyltransferase has a significant relation with magnesium levels in alcoholic liver disease.
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