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Year : 2021  |  Volume : 11  |  Issue : 5  |  Page : 211-215

Clinical evaluation of dyslipidemia among type 2 diabetes and hypothyroidism patients

Department of Pharmacology, GITAM Institute of Pharmacy, GITAM Deemed to be University, Visakhapatnam, Andhra Pradesh, India

Correspondence Address:
Dr. Arun Koyyada
GITAM Institute of Pharmacy, GITAM Deemed to be University, Visakhapatnam, Andhra Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/cmrp.cmrp_86_20

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Aim: To evaluate the lipid profiles among type 2 diabetes and hypothyroid patients for establishing relation between dyslipidemia, diabetes and thyroid disorders. Background: Dyslipidaemia is the leading cause of death in cardiovascular disease (CVD) patients. Diabetes and hypothyroidism are the two main endocrine risk factors for dyslipidaemia. Diabetes is associated with altered metabolism of triglyceride (TG) levels and low-density lipoprotein (LDL) levels. Hypothyroidism leads to decreased clearance of TG and catabolism of LDL. Materials and Methods: This was a cross-sectional with 288 subjects that include normal population, diabetic and hypothyroid patients. The plasma lipid levels, thyroid profile and glucose levels were collected from the patients. The data were subjected to an unpaired t-test for statistical analysis. The P < 0.05 is indicative of statistical significance. Results: The study included 288 patients out of which 104 were with type 2 diabetes, 81 were hypothyroid and 103 were controls. Dyslipidaemia cases found among them were 63, 26 and 32, respectively. The mean values of lipid levels in type 2 diabetes, hypothyroidism and control population were total cholesterol (TC) (211.4 ± 4.24, 190.5 ± 3.57 mg/dl and 187.3 ± 1.91 mg/dl), LDL (134.5 ± 3.01, 120.8 ± 2.035 and 115.8 ± 1.64 mg/dl), TG (188.6 ± 4.14, 169.9 ± 0.74 and 163.2 ± 2.42 mg/dl), high-density lipoprotein (HDL) (39.64 ± 0.45, 38.78 ± 0.49 and 38.64 ± 0.12 mg/dl) and non-HDL (171.75 ± 1.52, 151.75 ± 0.99 and 148.84 ± 1.99 mg/dl), respectively. Lipid levels of type 2 diabetes and hypothyroidism patients were found to be significantly more than the control population. The mean levels of TC, LDL, TG in type 2 diabetes and LDL, TG in hypothyroidism patients were found to be more than the normal range. Conclusion: There was a significant relationship between type 2 diabetes, hypothyroidism and dyslipidaemia. Routine lipid profile monitoring in patients with diabetes and hypothyroid disorders is advisable for the primary prevention of dyslipidaemia and CVD.

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